Vol. 104 No. 11 (2025), Původní práce
Vol. 104 No. 11 (2025)

Preoperative parathyroid hormone level as a predictor of parathyroid adenoma size in surgically treated patients with primary hyperparathyroidism

Původní práce
Published 2025-11-30
Adam Husek
1. LF UK, Prague
https://orcid.org/0009-0002-6186-0795
Stepanka Erbertova
1. LF UK, Prague
Stefan Popov
1. LF UK, Prague
Jiri Sedy
Institute of Dentistry and Oral Sciences, LF UP, Olomouc; Institute of Anatomy 2. LF UK, Prague
https://orcid.org/0000-0002-6597-5939
Marketa Vaculova
3rd Surgical Clinic of 1. LF UK and FN Motol, Prague
https://orcid.org/0000-0002-5786-3080
Petr Libansky
3rd Surgical Clinic of 1. LF UK and FN Motol, Prague
https://orcid.org/0000-0001-7093-3162
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Keywords

primary hyperparathyroidism
adenoma
parathormone
parathyroidectomy

Categories

Abstract

Introduction: Primary hyperparathyroidism (PHPT) is most commonly caused by a solitary parathyroid adenoma. The relationship between parathyroid hormone (PTH) lev­els and adenoma size remains unclear.

Methods: A retrospective analysis of 377 PHPT patients who underwent surgery at Third Department of Surgery, First Faculty of Medicine, Charles University and Motol University Hospital (2022–2023). Adenoma volume was calculated as an ellipsoid. The cor­relation between PTH and adenoma volume was assessed using regression analysis.

Results: A weak to moderate correlation was found (R = 0.315; P < 0.001). Linear regres­sion showed that a 1 pmol/L increase in PTH corresponded to an average adenoma volume increase of 104 mm³.

Conclusion: Preoperative PTH levels partially correlate with adenoma volume, but their predictive value is limited.

 

doi: 10.48095/ccrvch2025

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